https://support.eset.com/kb2299

• 
  Supported Operating Systems:
  
  Microsoft Windows Server 2003 SP2 (x86 and x64)
  Microsoft Windows Server 2003 R2 (x86 and x64)
  Microsoft Windows Server 2008 (x86 and x64)
  Microsoft Windows Server 2008 R2
  Microsoft Windows Server 2012
  Microsoft Windows Server 2012 R2
  Microsoft Windows Server 2016
  Microsoft Windows Small Business Server 2003 (x86)
  Microsoft Windows Small Business Server 2003 R2 (x86)
  Microsoft Windows Small Business Server 2008 (x64)
  Microsoft Windows Small Business Server 2011 (x64)
   

• ESET File Security for Microsoft Windows Server: For use on any supported Windows Server Operating System that is not intending to cover the Exchange stores.
  
  Supported operating systems:
  
  Microsoft Windows Server 2003 (x86 and x64)
  Microsoft Windows Server 2003 R2 (x86 and x64)
  Microsoft Windows Server 2008 (x86 and x64)
  Microsoft Windows Server 2008 R2
  Microsoft Windows Server 2012
  Microsoft Windows Server 2012 R2
  Microsoft Windows Server 2016
  Microsoft Windows Storage Server 2008 R2 Essentials SP1
  Microsoft Windows Storage Server 2012
  Microsoft Windows Storage Server 2012 R2
  Microsoft Windows Small Business Server 2003 (x86)
  Microsoft Windows Small Business Server 2003 R2 (x86)
  Microsoft Windows Small Business Server 2008 (x64)
  Microsoft Windows Small Business Server 2011 (x64)
  Microsoft Windows Server 2012 Essentials
  Microsoft Windows Server 2012 R2 Essentials
  Microsoft Windows Server 2016 Essentials
  Microsoft Windows MultiPoint Server 2010
  Microsoft Windows MultiPoint Server 2011
  Microsoft Windows MultiPoint Server 2012
   

ESET File Security for Microsoft Windows Server has been specifically designed to run on servers. For more information, see the following article: 

• Why should I upgrade to ESET File Security for Microsoft Windows Server?

ESET NOD32 Antivirus Business Edition and ESET Smart Security Business Edition are designed for use on workstations. However, the Business Edition products are being replaced by ESET Endpoint Security and ESET Endpoint Antivirus for workstation installations. For more information on these products, see the Knowledgebase article below:

• ESET Endpoint Security and ESET Endpoint Antivirus - FAQ